Base de dados : HANSEN Pesquisa : GENETICA POPULACIONAL [Descritor de assunto] Referências encontradas : 3 [refinar] Mostrando: 1 .. 3   no formato [Detalhado]

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Id: 25112 Autor: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordell, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Título: Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Fonte: s.l; s.n; 2004. 12 p. tab, graf. Resumo: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1 alpha, CCL4/MIP-1 beta, CCL5/RANTES, CCR7, STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 indiciduals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatellites shows two peaks of linkage for leprosy at D17S250 (Zir score 2.34; P=0.01) and D17S1795 (Zir 2.67; P=O.004) and a single peack for tuberculosis at D17S250 (Zir 2.04; P=0.02). Combined analysis shows significant linkage (peak Zir 3.38) at D17S250, equivalent to an allele sharing LOD score 2.48 (P=0.0004). To determine whether one or multiple genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic association testing that was robust to family clustering demonstrated significant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4 Mb-CCL 18-32.3 kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibilitty genes acros 17q11.2 (AU). Descritores: HANSENIASE/genet HANSENIASE/imunol TUBERCULOSE/genet TUBERCULOSE/imunol CROMOSSOMOS HUMANOS PAR 17/imunol CROMOSSOMOS HUMANOS PAR 21/imunol - GENETICA POPULACIONAL Limites: HUMANO Localização: BR191.1; 09196/s

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Id: 18985 Autor: McGill, P. E; Oyoo, G. O Título: Rheumatic disorders in Sub-saharan Africa ..- Fonte: s.l; s.n; Apr. 2002. 3 p. . Resumo: OBJECTIVE: To review prevalence of rheumatic disorders in Sub-saharan Africa and in the context of current medical practice in the region assess the need for service and educational provision. DATA SOURCES: Medline, (English, French). Pre-Medline literature review from the 1950's (Current contents). Various conference reports including attendance at all three AFLAR (African League Against Rheumatism) congresses in the 1990's. Author's personal database. All cited references read in full. CONCLUSIONS: The evidence shows rheumatoid arthritis and systemic lupus erythematosus to be increasing in frequency in the indigenous populations of East, Central and South Africa but remaining rare in West Africans. Gout is now more prevalent than ever throughout the subcontinent. HIV has spawned a variety of previously rare spondyloarthropathies (reactive arthritis, psoriatic arthritis, enthesopathy) and changed the epidemiology of pyomyositis and osteomyelitis. Osteoarthritis is a universal problem. Juvenile chronic arthritis is not rare and rheumatic fever is common. Acute and chronic locomotor problems associated with diverse entities such as leprosy, brucellosis, meningococcus, alpha viruses, parasites, fluorosis, rickets and haemoglobinopathies enhance diagnostic diversity and therapeutic and educational requirements. Suggestions made to address the challenge posed by the burden of rheumatic disorders. (AU). Descritores: DOENCAS REUMATICAS/epidemiol DOENCAS REUMATICAS/etiol DOENCAS REUMATICAS/terap VIGILÂNCIA DA POPULACAO DETERMINACAO DE NECESSIDADES DE CUIDADOS DE SAUDE GENETICA POPULACIONAL RACA NEGRA/genet AFRICA AO SUL DO SAARA/epidemiol EFEITOS PSICO-SOCIAIS DA DOENCA - PREVALÊNCIA Limites: HUMANO CRIANÇA ADULTO IDOSO Meio Eletrônico: - . Localização: BR191.1; 09102/s

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Id: 18475 Autor: Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M; Hill, Adrian V. S Título: A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population ..- Fonte: s.l; s.n; 2002. 4 p. tab, graf. Resumo: A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. (AU). Descritores: MAPEAMENTO CROMOSSÔMICO CROMOSSOMOS HUMANOS PAR 20/genet MARCADORES GENETICOS/genet PREDISPOSICAO GENETICA PARA DOENÇA/genet GENETICA POPULACIONAL HANSENIASE/genet REPETICOES DE MICROSSATELITES/genet MYCOBACTERIUM LEPRAE INDIA Limites: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 08997/s

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